Does Modafinil show up on a drug screen? Questions and Answers › Category: Questions › Does Modafinil show up on a drug screen? 0 Vote Up Vote Down Anonymous asked 5 years ago subj popular answer @In answer to your question, yes it will. Best of wishes and take the Provigil only as directed by your physician@, but anything else? admin Staff replied 5 years ago For most drugs tests “no”. This medicine is typically not something the drug tests are trying to pick up.