How do caffeine and modafinil interact? Questions and Answers › Category: Questions › How do caffeine and modafinil interact? 0 Vote Up Vote Down Anonymous asked 8 years ago Caffeine and modafinil have similar effects. What happens if you take them together? E.g., if you are already caffeinated, does the modafiinl do nothing more? Do the effects add? Is there some synergistic effect?